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Tocris Bioscience™ MS 436
Potent and selective BRD4(1) inhibitor
Supplier: Tocris Bioscience™ 5173/10
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Description
MS 436 is a potent and selective BRD4 bromodomain inhibitor (Ki = 30 - 50 nM for the first bromodomain (BRD4(1)). Exhibits 10-fold selectivity for BRD4(1) over BRD4(2). Blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC50 values are 3.8 and 4.9 μM, respectively). Attenuates melanoma cell proliferation in vitro.Specifications
>98% | |
MS 436 | |
MS 436 |
10 mg | |
383.42 |
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