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Tocris Bioscience™ LM11A 31 dihydrochloride
Nonpeptide p75NTR ligand; neuroprotective
Supplier: Tocris Bioscience™ 5046/50
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Description
LM11A 31 dihydrochloride is a nonpeptide p75NTR ligand and nerve growth factor (NGF) antagonist. LM11A 31 blocks p75-mediated cell death, inhibits proNGF induced cell death (IC50 = 1-10 nM), increases proliferation and survival of hippocampal neural progenitors and inhibits Aβ-induced cell death (EC50 = 20 nM). In animal models of Alzheimer's disease LM11A 31 prevents and reverses atrophy of cholinergic neurites and reverses Alzheimer's pathology; in models of Huntington's disease LM11A 31 increases survival, reduces the formation of aggregates of mutant huntingtin and neuronal degeneration. Also promotes functional recovery in a mouse model of spinal cord injury. Orally available and brain penetrant.Specifications
| 95% | |
| 1243259-19-9 | |
| 50 mg | |
| M.W. (Observed): 316.27 |
| (2 S,3 S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide dihydrochloride | |
| Desiccate at RT | |
| LM11A 31 dihydrochloride | |
| LM11A 31 dihydrochloride |
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