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LIN28 1632, >98%, Tocris Bioscience™
RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor
Supplier: R&D Systems 6068/50
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Description
Lin28 1632 is an RNA binding protein Lin28 inhibitor (IC50 = 8 μM). Lin28 1632 blocks binding of Lin28 to let-7 pre-micro RNA. Lin28 1632 inhibits stemness and induces differentiation of murine ESCs. Lin28 1632 increases let-7 miRNA and suppresses PD-L1 expression in multiple human cancer cell lines. Lin28 1632 inhibits growth of tumor cell lines and tumor-sphere formation in vitro. Lin28 1632 also inhibits growth of tumor xenografts in mice by enhancing T cell-mediated antitumor immunity . Lin28 1632 is also bromodomain inhibitor. Lin28 1632 inhibits tumor growth and metastasis in vivo in immunodeficient orthotopic mouse models of human breast cancer cell MDA-MB-231.Specifications
| N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide | |
| >98% | |
| 50 mg | |
| 281.31 |
| 108825-65-6 | |
| C15H15N5O | |
| Soluble to 100mM in DMSO and to 100mM in ethanol |
Safety and Handling
Recommended Storage : Store at 4°C
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