LIN28 1632, >98%, Tocris Bioscience™

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

Supplier:  R&D Systems 6068/10

Catalog No. 60-681-0

Description

Lin28 1632 is an RNA binding protein Lin28 inhibitor (IC50 = 8 μM). Lin28 1632 blocks binding of Lin28 to let-7 pre-micro RNA. Lin28 1632 inhibits stemness and induces differentiation of murine ESCs. Lin28 1632 increases let-7 miRNA and suppresses PD-L1 expression in multiple human cancer cell lines. Lin28 1632 inhibits growth of tumor cell lines and tumor-sphere formation in vitro. Lin28 1632 also inhibits growth of tumor xenografts in mice by enhancing T cell-mediated antitumor immunity . Lin28 1632 is also bromodomain inhibitor. Lin28 1632 inhibits tumor growth and metastasis in vivo in immunodeficient orthotopic mouse models of human breast cancer cell MDA-MB-231.

Specifications

• Chemical Name or Material: N-Methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide
• Purity Grade Notes: >98%
• Linear Formula: C₁₅H₁₅N₅O
• Synonym: n-methyl-n-3-3-methyl 1,2,4 triazolo 4,3-b pyridazin-6-yl phenyl acetamide, acetamide,n-methyl-n-3-3-methyl-1,2,4-triazolo 4,3-b pyridazin-6-yl phenyl, n-methyl-n-3-3-methyl-1,2,4 triazolo 4,3-b pyridazin-6-yl phenyl acetamide, maybridge3_006077, unii-ws1r0n3h0n, acmc-1c5o3, ws1r0n3h0n, acetamide, n-methyl-n-3-3-methyl-1,2,4-triazolo 4,3-b pyridazin-6-yl phenyl
• InChI Key: WPAQLESUVYGUJZ-UHFFFAOYSA-N
• IUPAC Name: N-methyl-N-[3-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide
• PubChem CID: 2737312

• CAS: 108825-65-6
• Molecular Formula: C15H15N5O
• Quantity: 10 mg
• Solubility Information: Soluble to 100mM in DMSO and to 100mM in ethanol
• SMILES: CC1=NN=C2N1N=C(C=C2)C3=CC(=CC=C3)N(C)C(=O)C
• Molecular Weight (g/mol): 281.319
• Formula Weight: 281.31

Safety and Handling

Recommended Storage : Store at 4°C