Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
T 0901317, Tocris Bioscience™
Click to view available options
Quantity:
10 mg
50 mg
Description
Potent, high affinity liver X receptor (LXR) agonist (EC50 ∽ 50 nM, Kd values are 7 and 22 nM for LXR-α and LXR-β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid-β production in primary neurons in vitro. Displays an EC50 of ∽ 5 μM for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid. Also exhibits inverse agonist activity at constitutive androstane receptors (CAR).
Specifications
Quantity | 50 mg |
Formula Weight | 481.33 |
Percent Purity | >98% |
Chemical Name or Material | T 0901317 |
Safety and Handling
Recommended Storage | Store at +4°C |
Provide Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?
Provide Content Correction