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  7. SP 600125, Tocris Bioscience™

SP 600125, Tocris Bioscience™

Catalog Number 149650
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
129-56-6
C14H8N2O
220.231
ACPOUJIDANTYHO-UHFFFAOYSA-N
1,9-pyrazoloanthrone, pyrazolanthrone, dibenzo cd,g indazol-6 2h-one, pyrazoleanthrone, anthra 1,9-cd pyrazol-6 2h-one, anthra-1,9-pyrazol-6-none, 2h-dibenzo cd,g indazol-6-one, jnk inhibitor ii, sapk inhibitor ii
8515
C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O
This item is not returnable. View return policy
129-56-6
C14H8N2O
220.231
ACPOUJIDANTYHO-UHFFFAOYSA-N
1,9-pyrazoloanthrone, pyrazolanthrone, dibenzo cd,g indazol-6 2h-one, pyrazoleanthrone, anthra 1,9-cd pyrazol-6 2h-one, anthra-1,9-pyrazol-6-none, 2h-dibenzo cd,g indazol-6-one, jnk inhibitor ii, sapk inhibitor ii
8515
C1=CC=C2C(=C1)C3=NNC4=CC=CC(=C43)C2=O

Description

Selective JNK inhibitor

SP 600125 is a selective JNK inhibitor. Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes. Active in vivo. Exhibits reduced selectivity over other protein kinases under certain conditions. SP 600125 protects renal tubular epithelial cells from ischemia/reperfusion-induced apoptosis. Promotes chondrogenesis of bone mesenchymal stem cells by inhibition of TNF-α-induced inflammation. Adipogenesis from MSCs is also promoted by SP 600125. Essential component of medium for maintaining stem cells in naive pluripotent state.
Quantity 50 mg
Formula Weight 220.23
Percent Purity >98%
Chemical Name or Material SP 600125

Safety and Handling

Recommended Storage Desiccate at -20°C
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