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Tocris Bioscience™ Ro 5-3335

Core binding factor inhibitor; attenuates hematopoiesis

Supplier:  Tocris Bioscience™ 4694/10

Catalog No. 46-941-0


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Description

Description

Ro 5-3335 is a core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Reduces leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. Also a Tat antagonist; inhibits HIV-1 replication in vitro.
Specifications

Specifications

>98%
10 mg
259.69
CBFβ-Runx1 inhibitor II
Ro 5-3335
Ro 5-3335
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