Thermo Scientific™ LC-SPDP (succinimidyl 6-(3(2-pyridyldithio)propionamido)hexanoate)

Crosslink amines to sulfhydryls with this crosslinker composed of NHS-ester and pyridyldithiol groups at ends of 10-atom (15.7A) spacer arm.

Supplier:  Thermo Scientific™ 21651

Catalog No. PI21651

Description

Thermo Scientific™ Pierce LC-SPDP is a long-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.

Highlights:

• Forms cleavable disulfide bonds with sulfhydryls
• Releases a detectable byproduct after reacting with a free sulfhydryl group; by measuring the release of pyridine-2-thione at 343nm, the reaction can be monitored
• Reactive groups: NHS ester and pyridyldisulfide
• Reactive toward: amino and sulfhydryl groups

Specifications

• Chemical Reactivity: Amine-Sulfhydryl
• Description: LC-SPDP
• PEGylated: No
• Content And Storage: Upon receipt store at 4°C protected from moisture.
• Shipping Condition: Ambient
• Labeling Method: Chemical Labeling
• Reactive Moiety: NHS Ester, Pyridyldisulfide
• Form: Powder
• Solubility: DMF, DMSO
• Water Soluble: No

• Cleavable: By Thiols
• Molecular Weight (g/mol): 425.52
• Spacer Arm Length: 15.7 Å
• Cell Permeability: Yes
• Product Line: Pierce™
• Crosslinker Type: Heterobifunctional
• Spacer: Medium (10 to 30 Å)
• Quantity: 50 mg
• Format: Standard
• Product Type: Crosslinker

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov

For Research Use Only. Not for use in diagnostic procedures.