Phenyl chloroformate, 99%, Thermo Scientific Chemicals

Description

Phenyl chloroformate is used in the synthesis of poly(2-(phenoxycarbonyloxy)ethyl methacrylate) and phenyl-(4-vinylphenyl) carbonate. It acts as a precursor of phenyl mixed anhydrides which are used in peptide coupling reactions. It serves as a dehydrating reagent for the conversion of primary amides to nitriles and an intermediate in the synthesis of pharmaceuticals and carbamates.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Phenyl chloroformate is used in the synthesis of poly(2-(phenoxycarbonyloxy)ethyl methacrylate) and phenyl-(4-vinylphenyl) carbonate. It acts as a precursor of phenyl mixed anhydrides which are used in peptide coupling reactions. It serves as a dehydrating reagent for the conversion of primary amides to nitriles and an intermediate in the synthesis of pharmaceuticals and carbamates.

Solubility
Miscible with N,N-dimethylformamide.

Notes
Store in cool place. Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with bases, alcohols and amines. Hydrolyses in water.

Specifications

Chemical Identifiers

• CAS: 1885-14-9
• Molecular Formula: C7H5ClO2
• Molecular Weight (g/mol): 156.57
• MDL Number: MFCD00000637
• InChI Key: AHWALFGBDFAJAI-UHFFFAOYSA-N
• Synonym: phenyl chloroformate, chloroformic acid phenyl ester, phenyl chlorocarbonate, carbonochloridic acid, phenyl ester, phenoxycarbonyl chloride, formic acid, chloro-, phenyl ester, fenylester kyseliny chlormravenci, phenylchloroformate, unii-6tnd0d6d3y, 6tnd0d6d3y
• PubChem CID: 15891
• IUPAC Name: phenyl carbonochloridate
• SMILES: ClC(=O)OC1=CC=CC=C1

• Melting Point: -38°C
• Density: 1.246
• Boiling Point: 188°C to 189°C
• Flash Point: 76°C (169°F)
• Refractive Index: 1.511
• Quantity: 100 g
• UN Number: UN2746
• Beilstein: 606778
• Sensitivity: Moisture sensitive
• Solubility Information: Miscible with N,N-dimethylformamide.
• Formula Weight: 156.57
• Percent Purity: 99%
• Chemical Name or Material: Phenyl chloroformate

Safety and Handling

Hazard Category	H227-H302-H314-H317-H330-H335
Hazard Statement	GHS H Statement H330-H314-H318-H227-H302-H317 Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Combustible liquid. Harmful if swallowed. May cause an allergic skin reaction.
Precautionary Statement	P210-P235-P260-P264b-P270-P271-P272-P280-P284-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P333+P313-P363-P370+P378q-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: II; Proper Shipping Name: PHENYL CHLOROFORMATE
EINECSNumber	217-547-8
RTECSNumber	FG3850000
TSCA	Yes
Recommended Storage	Keep cold; Store under Nitrogen

SDS

RUO – Research Use Only