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AdipoGen Okadaic acid NH4 high purity
SDP

Supplier:  AdipoGen AGCN20058C025

Encompass_Preferred

Chemical. CAS 175522-42-6. Formula C44H67O13 . NH4. MW 804.0 . 18.0. Isolated from Prorocentrum concavum. Salt form generated in aqueous ammonium hydroxide-methanol solution. Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A IC50=0.2-1nM, PP1 IC50=3-15nM, PP2B IC50= >1µM. Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C zeta/lambda in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells MB-231 and MCF-7 and in myeloid cells. Neurotoxic.

Catalog No. 50-256-2679


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