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  8. NS 11021, Tocris Bioscience™

NS 11021, Tocris Bioscience™

Catalog No. 478850
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Activator of BKCa (KCa1.1) channels

Activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Exhibits no modulatory effect on a variety of K+ (KV), Na+ and Ca2+ currents at concentrations <10 μM. Alters gating kinetics, but does not affect single channel conductance. Shown to bind BKCa in open and closed conformations; thought to bind the α subunit.

Chemical Identifiers

CAS 956014-19-0
Molecular Formula C16H9BrF6N6S
Molecular Weight (g/mol) 511.244
InChI Key MDKAFDIKYQMOMF-UHFFFAOYSA-N
Synonym 1-3,5-bis trifluoromethyl phenyl-3-4-bromo-2-2h-tetrazol-5-yl phenyl thiourea, 1-3,5-bis-trifluoromethyl-phenyl-3-4-bromo-2-1h-tetrazol-5-yl-phenyl-thiourea, thiourea, n'-3,5-bis trifluoromethyl phenyl-n-4-bromo-2-2h-tetrazol-5-yl phenyl, n'-3,5-bis trifluoromethyl phenyl-n-4-bromo-2-2h-tetrazol-5-yl phenyl-thiourea, n'-3,5-bis trifluoromethyl phenyl-n-4-bromo-2-2h-tetrazol-5-yl-phenyl thiourea, 1-3,5-bis trifluoromethyl phenyl-3-4-bromo-2-1h-1,2,3,4-tetrazol-5-yl phenyl thiourea, 1-3,5-bis trifluoromethyl phenyl-3-4-bromo-2-2h-1,2,3,4-tetrazol-5-yl phenyl thiourea, 3-3,5-bis trifluoromethyl phenyl-1-4-bromo-2-1h-1,2,3,4-tetrazol-5-yl phenyl thiourea, 3-3,5-bis trifluoromethyl phenyl-1-4-bromo-2-2h-1,2,3,4-tetrazol-5-yl phenyl thiourea
PubChem CID 24825677
IUPAC Name 1-[3,5-bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]thiourea
SMILES C1=CC(=C(C=C1Br)C2=NNN=N2)NC(=S)NC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F

Specifications

Quantity 50 mg
Formula Weight 511.24
Percent Purity >98%
Chemical Name or Material NS 11021

Safety and Handling

Recommended Storage Store at -20°C
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