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  7. Necrostatin-1, Tocris Bioscience™

Necrostatin-1, Tocris Bioscience™

Catalog No. 232450
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

RIP1 kinase inhibitor; inhibits necroptosis

ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.

Chemical Identifiers

CAS 4311-88-0
Molecular Formula C13H13N3OS
Molecular Weight (g/mol) 259.327
InChI Key TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Synonym necrostatin-1, mth-dl-tryptophan, nec-1, necrostatin 1, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo-4-imidazolidinone, mth-trp, methyl-thiohydantoin-tryptophan, necroptotic inhibitor, nec-1, 5-1h-indol-3-ylmethyl-3-methyl-2-sulfanylideneimidazolidin-4-one, 4-imidazolidinone, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo
PubChem CID 2828334
IUPAC Name 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one
SMILES CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32

Specifications

Quantity 50 mg
Formula Weight 259.33
Percent Purity 98%
Chemical Name or Material Necrostatin-1

Safety and Handling

Recommended Storage Store at Room Temperature
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