Methyl diethylphosphonoacetate, 97%, Thermo Scientific Chemicals

Description

Methyl diethylphosphonoacetate is used as a reagent in the preparation of allylic fluorides compounds and in regioselective Diels-Alder reactions. It also serves as a reactant in the preparation of substituted thiophenes and furans, which finds application in type 2 diabetes treatment. Further, it acts as a precursor in the synthesis of pyridone alkaloids and immunosuppressive cyclopentanediol derivatives. In addition to this, it is utilized in the modification of botulinum neurotoxin serotype A protease inhibitors.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Methyl diethylphosphonoacetate is used as a reagent in the preparation of allylic fluorides compounds and in regioselective Diels-Alder reactions. It also serves as a reactant in the preparation of substituted thiophenes and furans, which finds application in type 2 diabetes treatment. Further, it acts as a precursor in the synthesis of pyridone alkaloids and immunosuppressive cyclopentanediol derivatives. In addition to this, it is utilized in the modification of botulinum neurotoxin serotype A protease inhibitors.

Solubility
Miscible with tetrahydrofuran.

Notes
Incompatible with strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 1067-74-9
• Molecular Formula: C7H15O5P
• Molecular Weight (g/mol): 210.166
• MDL Number: MFCD00009081
• InChI Key: CTSAXXHOGZNKJR-UHFFFAOYSA-N
• Synonym: methyl diethylphosphonoacetate, methyl 2-diethoxyphosphoryl acetate, acetic acid, diethoxyphosphinyl-, methyl ester, diethylmethylphosphonoacetate, methyl diethoxyphosphoryl acetate, diethyl carbomethoxymethylphosphonate, methyl 2-diethoxycarbonyl acetate, methyldiethylphosphonoacetate, diethyl methylphosphonoacetate, ksc489e0f
• PubChem CID: 66113
• IUPAC Name: methyl 2-diethoxyphosphorylacetate
• SMILES: CCOP(=O)(CC(=O)OC)OCC

• Density: 1.145
• Boiling Point: 126°C to 128°C (8 mmHg)
• Flash Point: >110°C (230°F)
• Refractive Index: 1.432
• Quantity: 500 g
• Beilstein: 1782397
• Solubility Information: Miscible with tetrahydrofuran.
• Formula Weight: 210.17
• Percent Purity: 97%
• Chemical Name or Material: Methyl diethylphosphonoacetate

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	213-938-2
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only