Hypoxanthine, 99%, Thermo Scientific Chemicals

Description

Hypoxanthine, is used as a marker for energy perturbation in hypoxia/ ischemia. It has been also used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol A (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus. It is also used as a pharmaceutical intermediate.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Hypoxanthine, is used as a marker for energy perturbation in hypoxia/ ischemia. It has been also used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol å (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus. It is also used as a pharmaceutical intermediate.

Solubility
It does not mix appreciably with water (1:1400). Small octahedra crystals from water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible to Strong oxidizing agents. Stable under recommended storage conditions. Sterilize by filtration through a 0.22 µm filter.

Specifications

Chemical Identifiers

• CAS: 68-94-0
• Molecular Formula: C5H4N4O
• Molecular Weight (g/mol): 136.11
• MDL Number: MFCD00005725
• InChI Key: FDGQSTZJBFJUBT-UHFFFAOYSA-N
• Synonym: hypoxanthine, 6-hydroxypurine, 9h-purin-6-ol, sarkin, 6-oxopurine, sarcine, sarkine, 3h-purin-6-ol, 7h-purin-6-ol, purin-6 1h-one
• PubChem CID: 790
• ChEBI: CHEBI:17368
• IUPAC Name: 3,7-dihydropurin-6-one
• SMILES: O=C1N=CNC2=C1NC=N2

• Melting Point: >300°C
• Quantity: 25 g
• Beilstein: 5811
• Merck Index: 14,4869
• Solubility Information: It does not mix appreciably with water (1:1400). Small octahedra crystals from water.
• Formula Weight: 136.11
• Percent Purity: 99%
• Chemical Name or Material: Hypoxanthine

Safety and Handling

Hazard Category	H302-H315-H319-H335
Precautionary Statement	P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
EINECSNumber	200-697-3
RTECSNumber	UP0791000
TSCA	Yes
Recommended Storage	Keep cold

SDS

RUO – Research Use Only