Invitrogen™ Human Stem Cell Factor (SCF) Synthetic Peptide

Synthetic Peptide

Supplier:  Invitrogen™ PEP0860

Catalog No. PEP0860

Description

SCF Synthetic Peptide, PEP-0860, from Invitrogen.

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist. This peptide corresponds to 18 amino acids near the center of human SCF.PEP-0860 can be used as a blocking peptide with polyclonal antibody PA5-20746.

Specifications

• Gene ID (Entrez): 4254
• Purification Method: purified
• Common Name: Human Stem Cell Factor (SCF)
• Content And Storage: -20°C
• Format: Liquid
• For Use With (Application): Blocking Assay, Control
• Lyophilized: No
• Product Type: Peptide
• Regulatory Status: RUO - research use only

• Species: Human
• Accession Number: P21583
• Concentration: 200 μg/mL
• Description: Synthetic Peptide
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
• Gene Symbol: KITLG
• Preservative: 0.02% sodium azide
• Quantity: 50 μg
• Storage Buffer: PBS