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GSK 2334470, Tocris Bioscience™
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Quantity:
10 mg
50 mg
Description
Potent 3-phosphoinositide-dependent protein kinase (PDPK1) inhibitor (IC50 ∽ 10 nM). Exhibits no effect on other kinases including Aurora, ROCK, p38 MAPK and PI 3-K. Suppresses T-loop phosphorylation and subsequent activation of PDK1 substrates S6K1, SGK and RSK in vitro; exhibits limited inhibitory effect on Akt activation. Delays melanomagenesis and metastasis in BrafV600E::Pten(-/-) mice.
Specifications
Quantity | 50 mg |
Formula Weight | 462.59 |
Percent Purity | >98% |
Chemical Name or Material | GSK 2334470 |
Safety and Handling
Recommended Storage | Store at +4°C |
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