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List Biological Laboratories Inc Diphtheria Toxin CRM197 Mutant, Native, 0.25 mg
Supplier: List Biological Laboratories Inc 149A
Since 1978, List Labs products are unsurpassed in quality, consistency, and reliability for the success of your research and development project! Cross reacting material (CRM197) is a nontoxic variant of diphtheria toxin with a single mutation (resulting in a Glycine to Glutamate substitution at postion 52). CRM functions as a carrier protein for polysaccharides and haptens making them immunogenic. CRM is widely used in polysaccharde conjugate vaccines. CRM197 has the advantage of being a well defined protein in contrast to formaldehyde treated toxin (toxoid) which is non-specifically cross linked and subject to rearrangement and loss of epitopes. List Labs CRM197 is purified from the native mutant strain maintaining structural and immunological integrity.
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