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  7. (-)-Cotinine, 98%, Thermo Scientific Chemicals

(-)-Cotinine, 98%, Thermo Scientific Chemicals

Catalog Number AAL1187303
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Quantity:
250 mg
1 g
486-56-6
C10H12N2O
176.219
MFCD00077696
UIKROCXWUNQSPJ-VIFPVBQESA-N
cotinine, --cotinine, cotinina, cotininum, cotinine-, s-cotinine, s---cotinine, unii-k5161x06ll, s-1-methyl-5-3-pyridinyl-2-pyrrolidinone, 2-pyrrolidinone, 1-methyl-5-3-pyridinyl-, 5s
854019
CHEBI:68641
(5S)-1-methyl-5-pyridin-3-ylpyrrolidin-2-one
CN1C(CCC1=O)C2=CN=CC=C2
486-56-6
C10H12N2O
176.219
MFCD00077696
UIKROCXWUNQSPJ-VIFPVBQESA-N
cotinine, --cotinine, cotinina, cotininum, cotinine-, s-cotinine, s---cotinine, unii-k5161x06ll, s-1-methyl-5-3-pyridinyl-2-pyrrolidinone, 2-pyrrolidinone, 1-methyl-5-3-pyridinyl-, 5s
854019
CHEBI:68641
(5S)-1-methyl-5-pyridin-3-ylpyrrolidin-2-one
CN1C(CCC1=O)C2=CN=CC=C2

Description

(-)-Cotinine is used to activate a subpopulation of α3/ α6β2 nAChRs in monkey striatum. It binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature is 2 - 8°C.
TRUSTED_SUSTAINABILITY
Melting Point 34°C to 39°C
Boiling Point 145°C to 147°C (3 mmHg)
Flash Point >110°C (230°F)
Quantity 1 g
Beilstein 83099
Merck Index 14,2553
Solubility Information Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM),ethanol (50mg/ml,yielding a clear,faint yellow to yellow solution),methanol and chloroform.
Optical Rotation −20° (c=1 in Ethanol)
Formula Weight 176.22
Percent Purity 98%
Chemical Name or Material (-)-Cotinine
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Safety and Handling

Hazard Category H302-H315-H319-H335
Hazard Statement GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary Statement P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
EINECSNumber 207-634-9
RTECSNumber GN1925500
TSCA No
Recommended Storage Keep cold
SDS

RUO – Research Use Only

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