Chloromethyl methyl sulfide, 94%, Thermo Scientific Chemicals

Description

Chloromethyl methyl sulfide is used as a methylene transfer reagent for iron(II) mediated cyclopropanation and for carbonyl and aromatic compounds. It protects alcohols as their methylthiomethyl (MTM) ethers by reaction, e.g. with NaH/NaI in DME. It is also used for the preparation of MTM esters of carboxylic acids, e.g. by treatment of the K salt of the acid in the presence of NaI and 18-crown-6 and for reaction with cyclopentadienyl iron dicarbonyl dimer in the formation of an iron-containing methylene transfer agent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Chloromethyl methyl sulfide is used as a methylene transfer reagent for iron(II) mediated cyclopropanation and for carbonyl and aromatic compounds. It protects alcohols as their methylthiomethyl (MTM) ethers by reaction, e.g. with NaH/NaI in DME. It is also used for the preparation of MTM esters of carboxylic acids, e.g. by treatment of the K salt of the acid in the presence of NaI and 18-crown-6 and for reaction with cyclopentadienyl iron dicarbonyl dimer in the formation of an iron-containing methylene transfer agent.

Solubility
Soluble in acetonitrile, ether and dichloromethane. Insoluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: 2 - 8°C. Incompatible with strong oxidizing agents.

Specifications

• Density: 1.16
• Boiling Point: 104°C to 105°C
• Flash Point: 17°C (62°F)
• Odor: Stench
• Refractive Index: 1.498
• Quantity: 10 g
• UN Number: UN1993
• Beilstein: 1730851
• Sensitivity: Moisture sensitive
• Solubility Information: Soluble in acetonitrile,ether and dichloromethane. Insoluble in water.
• Formula Weight: 96.58
• Percent Purity: 95%
• Chemical Name or Material: Chloromethyl methyl sulfide

Safety and Handling

Hazard Category	H225-H315-H319-H335
Hazard Statement	GHS H Statement H225-H315-H319-H335 Highly flammable liquid and vapor. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P210-P233-P235-P240-P241-P242-P243-P261-P264b-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P332+P313-P363-P370+P378q-P501c
DOTInformation	Transport Hazard Class: 3; Packing Group: II; Proper Shipping Name: FLAMMABLE LIQUIDS, N.O.S.
EINECSNumber	219-148-4
RTECSNumber	WQ3700000
TSCA	No
Recommended Storage	Keep cold; Store under Nitrogen

SDS

RUO – Research Use Only