5,6-Dichlorobenzimidazole riboside, 98%, Thermo Scientific Chemicals

Description

Inhibits casein kinase II and blocks RNA synthesis. An adenosine analog.5,6-Dichlorobenzimidazole riboside is used as an inhibitor of RNA Polymerase II. It is nucleoside analogue and used in research to study the mechanisms of cellular regulation. Further, it inhibits some protein kinases.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Inhibits casein kinase II and blocks RNA synthesis. An adenosine analog.5,6-Dichlorobenzimidazole riboside is used as an inhibitor of RNA Polymerase II. It is nucleoside analogue and used in research to study the mechanisms of cellular regulation. Further, it inhibits some protein kinases.

Solubility
Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide, hot ethanol, dimethyl formamide, (1:2) dimethyl formamide:Phosphate buffer saline, water, methanol and pyridine. Slightly soluble in aqueous buffers.

Notes
Incompatible with heat and oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 53-85-0
• Molecular Formula: C12H12Cl2N2O4
• Molecular Weight (g/mol): 319.138
• MDL Number: MFCD00036785
• InChI Key: XHSQDZXAVJRBMX-DDHJBXDOSA-N
• Synonym: 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole, dichlororibofuranosylbenzimidazole, drb, 5,6-dichlorobenzimidazole riboside, 5,6-dichlorobenzimidazole 1-beta-d-ribofuranoside, 5,6-dichloro-1-.beta.-d-ribofuranosylbenzimidazole, benzimidazole, 5,6-dichloro-1-beta-d-ribofuranosyl, 5,6-dichloro-1-beta-d-ribofuranosyl-1h-benzimidazole, 2r,3r,4s,5r-2-5,6-dichloro-1,3-benzodiazol-1-yl-5-hydroxymethyl oxolane-3,4-diol, 2r,3r,4s,5r-2-5,6-dichloro-1h-1,3-benzodiazol-1-yl-5-hydroxymethyl oxolane-3,4-diol
• PubChem CID: 5894
• IUPAC Name: (2R,3R,4S,5R)-2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• SMILES: C1=C2C(=CC(=C1Cl)Cl)N(C=N2)C3C(C(C(O3)CO)O)O

• Color: White
• Quantity: 50 mg
• Beilstein: 39123
• Solubility Information: Soluble in DMSO to 75mMSoluble in dimethyl sulfoxide,hot ethanol,dimethyl formamide,(1:2) dimethyl formamide:Phosphate buffer saline,water,methanol and pyridine; Slightly soluble in aqueous buffers.
• Formula Weight: 319.14
• Percent Purity: 98%
• Physical Form: Powder
• Chemical Name or Material: 5,6-Dichlorobenzimidazole riboside

Safety and Handling

RTECSNumber	DD7310000
TSCA	No
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only