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2-APB, Tocris Bioscience™
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Quantity:
10 mg
50 mg
Description
A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist (IC50 = 42 μM). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 μM) and inhibits it at higher concentrations (up to 50 μM). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes.
Specifications
Specifications
Quantity | 50 mg |
Formula Weight | 225.1 |
Percent Purity | >98% |
Chemical Name or Material | 2-APB |
Safety and Handling
Recommended Storage | Store at Room Temperature |
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